NJPhAST Monthly Meeting
ABITEC Corporation will present at the March 20, 2014 meeting of the New Jersey Pharmaceutical Association for Science and Technology (NJPhAST). Damon Dalrymple, Director of Scientific and Regulatory Affairs will discuss "Lipid Chemistry: Current Research on Permeation Enhancement".
Due to the application of combinatorial chemistry and high-throughput screening in drug discovery, the majority of new drug candidates have become extremely insoluble in water making the development of bioavailable clinical dosage forms very challenging. Two-thirds of compounds emerging from the drug discovery pipeline have an aqueous solubility of less than 100 µg/mL (0.1 mg/mL). This would classify them as insoluble or practically insoluble according to the definitions of the United States Pharmacopeia.
Lipid-based drug delivery systems in which the drug is solubilized by lipids or lipid-like excipients, have been recognized as an attractive approach for increasing the bioavailability of these compounds. Lipids have been employed to improve the dissolution rate, increase the solubility of API in the intestinal fluid and influence permeability. Current and New information regarding the permeation enhancement of lipidic compounds acting towards BCS II, III and IV compounds will be discussed.Registration begins at 5:30 p.m., dinner served at 6:30 p.m., and Damon's presentation will start promptly at 7:30 p.m.
Location: Dolce Basking Ridge, 300 N Maple Ave, Basking Ridge, NJ 07920