Parenteral

The parenteral route of administration is the most effective route for the delivery of active pharmaceutical ingredients which exhibit poor bioavailability. ABITEC offers parenteral grade lipid excipients for improved solubilization of lipophilic drugs in the development of stable microemulsions and in the development of oleaginous solutions for use in parenteral dosage forms for controlled or modified drug delivery applications.

INJECTA™ parenteral grade lipid excipients enable improved solubilization of injectable active pharmaceutical ingredients (APIs).  INJECTA lipid excipients undergo secondary sterile filtration and aseptic processing in state-of-the-art facilities to ensure products are of the highest quality.  The entire INJECTA product line is tested for pyrogens, microbial contaminants, elemental impurities, and particulate matter by validated testing protocols. 

Overview

The majority of new chemical entities (NCEs) being considered for therapeutic applications are BCS (Biopharmaceutics Classification System) Class II, Class III, or Class IV, indicating that these potential API’s will exhibit solubility and/or permeability challenges. Functional lipids are one of the most widely employed excipient classes for overcoming reduced bioavailability due to both solubility and permeability challenges. Many API’s which are insoluble in aqueous media can be dissolved in functional lipids improving their solubility by means of generating an oil in water emulsion carrier system for the API. Additionally, functional lipids can overcome certain permeability issues associated with delivering API's.

Related Products

CAPTEX®

Captex medium-chain esters are preferred lipophilic vehicles and solvents, used alone or in combination with other excipients, in the development of solution, suspension, emulsion and microemulsion formulations for various delivery systems.

Product Name Chemical Name CAS Number
Captex INJ 300 Low C6 EP/NF/JPE* Glyceryl Tricaprylate/Tricaprate 65381-09-1, or
73398-61-5
Captex INJ 355 EP/NF/JPE* Glycerol Tricaprylate/Caprate 65381-09-1, or
73398-61-5
Captex INJ 8000* Glyceryl Tricaprylate 538-23-8

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*Developmental

CAPMUL®

This line of highly-functional, highly reproducible medium and long chain monoglycerides can be used alone as a primary solubilizer or in conjunction, as an emulsifier, with other ABITEC ingredients, in order to improve the bioavailability of active pharmaceutical ingredients. 

Product Name Chemical Name CAS Number
Capmul INJ MCM EP* Caprylic capric mono- & diglycerides  91744-32-0, or
26402-22-2, and 26402-26-6

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*Developmental

ACCONON®

Acconon excipients are well-characterized mixtures of polyoxyethylene mono- and diglycerides, fatty acids, or fatty alcohols. They are used to improve the bioavailability of poorly soluble drugs by direct solubilization or by acting as a stabilizing surfactant in active-carrying emulsions.

Product Name Chemical Name CAS Number
Acconon INJ MC8-2 EP/NF* PEG-8 caprylic/capric glycerides 91744-32-0, 223129-75-7

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*Developmental

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CAPTEX®, and CAPMUL® are registered trademarks of ABITEC Corporation. All information and statements given on this website are believed to be accurate at the time of publication. However, neither ABITEC Corporation nor any of their affiliates make any representations or warranty with respect thereto, including, but not limited to, any results obtained in the processing of the products by customers or any third party. All information and statements are intended for persons having the required skill and know-how and do not relieve the customer or user from verifying the suitability of information and statements given for a specific purpose prior to use of the products. It is entirely the obligation of the customer or user to comply with applicable laws and regulations, and also with all patent or other intellectual property rights of third parties. ABITEC CORPORATION EXPRESSELY DISCLAIMS ANY REPRESENTATIONS OR WARRANTIES OF ANY KIND, WHETHER EXPRESSED OR IMPLIED, AS TO THE ACCURACY, CURRENCY, COMPLETENESS AND/OR THE MERCHANTABILITY OR FITNESS OF A PARTICULAR PURPOSE OF ANY INFORMATION CONTAINED ON THIS WEBSITE AND/OR PRODUCT DESCRIBED OR PROMOTED ON THIS WEBSITE, INCLUDING WARRANTIES WITH RESPECT TO INFRINGEMENT OF ANY PATENT, COPYRIGHT, OR OTHER RIGHTS OF A THIRD PARTY. We reserve the right to change product specifications and specified properties of the products without prior notice.