Parenteral

The parenteral route of administration is the most effective route for the delivery of active pharmaceutical ingredients which exhibit poor bioavailability. ABITEC offers parenteral grade lipid excipients for improved solubilization of lipophilic drugs in the development of stable microemulsions and in the development of oleaginous solutions for use in parenteral dosage forms for controlled or modified drug delivery applications.

INJECTA™ parenteral grade lipid excipients enable improved solubilization of injectable active pharmaceutical ingredients (APIs).  INJECTA lipid excipients undergo secondary sterile filtration and aseptic processing in state-of-the-art facilities to ensure products are of the highest quality.  The entire INJECTA product line is tested for pyrogens, microbial contaminants, elemental impurities, and particulate matter by validated testing protocols. 

Overview

The majority of new chemical entities (NCEs) being considered for therapeutic applications are BCS (Biopharmaceutics Classification System) Class II, Class III, or Class IV, indicating that these potential API’s will exhibit solubility and/or permeability challenges. Functional lipids are one of the most widely employed excipient classes for overcoming reduced bioavailability due to both solubility and permeability challenges. Many API’s which are insoluble in aqueous media can be dissolved in functional lipids improving their solubility by means of generating an oil in water emulsion carrier system for the API. Additionally, functional lipids can overcome certain permeability issues associated with delivering API's.

Related Products

CAPTEX®

Captex medium-chain esters are preferred lipophilic vehicles and solvents, used alone or in combination with other excipients, in the development of solution, suspension, emulsion and microemulsion formulations for various delivery systems.

Product Name Chemical Name CAS Number
Captex INJ 300 Low C6 EP/NF/JPE* Glyceryl Tricaprylate/Tricaprate 65381-09-1, or
73398-61-5
Captex INJ 355 EP/NF/JPE* Glycerol Tricaprylate/Caprate 65381-09-1, or
73398-61-5
Captex INJ 8000 NF Glyceryl Tricaprylate 538-23-8

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*Developmental

CAPMUL®

This line of highly-functional, highly reproducible medium and long chain monoglycerides can be used alone as a primary solubilizer or in conjunction, as an emulsifier, with other ABITEC ingredients, in order to improve the bioavailability of active pharmaceutical ingredients. 

Product Name Chemical Name CAS Number
Capmul INJ MCM EP* Caprylic capric mono- & diglycerides  91744-32-0, or
26402-22-2, and 26402-26-6

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*Developmental

ACCONON®

Acconon excipients are well-characterized mixtures of polyoxyethylene mono- and diglycerides, fatty acids, or fatty alcohols. They are used to improve the bioavailability of poorly soluble drugs by direct solubilization or by acting as a stabilizing surfactant in active-carrying emulsions.

Product Name Chemical Name CAS Number
Acconon INJ MC8-2 EP/NF* PEG-8 caprylic/capric glycerides 91744-32-0, 223129-75-7

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*Developmental

Related Applications

Oral   topical & transdermal   suppositories   ophthalmic