Overcoming Drug Solubility Challenges: A Guide to Self-Emulsifying Drug Delivery Systems

Solubility in the gastrointestinal (GI) tract is essential for therapeutic effectiveness of oral drugs. However, an increasing number of modern drug candidates (around 40% of those approved and 90% of those in development) have poor aqueous solubility* limiting their GI dissolution, and thus their bioavailability.

Formulators can tackle poor solubility by simply increasing drug dosage but that risks increasing adverse effects*. Or they can use various solubility enhancement techniques which might require additional drug modifications, process complexity or specialized equipment.

Self-emulsifying drug delivery systems (SEDDS) have emerged as a compelling alternative, avoiding the trade-offs that come with these conventional approaches.

Learn how to overcome drug solubility challenges with self-emulsifying drug delivery systems