Excipients for Direct Compression Tablet Formulation
Highly reproducible excipients for direct compression tableting including lubricants, dry binders, sustained-release excipients, hot-melt granulation excipients and oil absorbing excipients.
What Is Direct Compression?
Direct compression refers to the process of forming tablets by compressing a powder blend directly into a solid form. It relies on two key mechanisms:
Compaction: The formation of a solid tablet from powder.
Compression: The reduction in powder volume under pressure.
The direct compression method is preferred for its minimal processing steps, reduced production time, and lower energy consumption.
The Role of Excipients in Direct Compression
Excipient selection and performance is critical to the manufacture of robust tablets by direct compression. However, not all excipients behave the same under compression. For example, lubricants like magnesium stearate, while effective at reducing ejection force, can inhibit bonding between particles, leading to weaker tablets.
ABITEC manufactures a variety of excipients suitable for a multitude of tableting applications. They include lubricants, dry-binders, excipients for sustained release, and oil absorbents.
Challenges with Tablet Lubricants
Lubricants are essential to prevent damage to tablet presses and ensure smooth ejection. But they can also:
- Reduce tablet hardness.
- Prolong disintegration and dissolution times.
- Interfere with active ingredient release.
How can ABITEC's innovative excipients for direct compressions help?

STEROTEX® Hydrogenated Vegetable Oil Powders
Flexible function in direct compression formulations: as a lubricant or a dry binder or as a sustained release excipient for both encapsulated or matrix formulations.
- Lubricates to reduce ejection force without affecting disintegration time or risk of overmixing.
- Binds with excellent plastic deformation to produce hard, durable tablets with low friability.
- Works with pore-forming excipients by hot-melt granulation or extrusions.
- Compatible with dry blending at various concentrations in erosion-based matrix systems.

ABISORB-DC™ Co-processed Excipient System
Take advantage of SEDDS formulations to enhance bioavailability whilst benefiting from the ease, economy and speed of direct compression.
- High lipid absorption capacity: 20-25% w/w lipid load.
- Forms durable tablets at standard industry tableting speeds.
- Allows full release of API upon dissolution.
- Absorbs fully dissolved or oil-suspended APIs for compaction into robust tablets.

CAPMUL GDB EP/NF Glyceryl Dibehenate
Excellent dry binding and plastic deformation - ideal for producing hard, durable tablets with low friability.
- Excellent compressibility with minimal elastic recovery.
- Improves tablet strength and reduces friability.
- Compatible with dry blending at various concentrations in erosion-based matrix systems.
- Works as a hydrophobic binder in hot-melt granulation and extrusion to control drug release
Why choose ABITEC for direct compression solutions?
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ABITEC is is a global leader in the development and manufacture of highly reproducible, compendial lipid excipients for the pharmaceutical industry.
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We have spent over 50 years producing high-quality ingredients with world-class technical, scientific, regulatory and manufacturing expertise.
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Our pharmaceutical grade lipid excipients are manufactured under strict cGMP in an FDA-audited, state-of-the-art facility in Janesville, WI (USA).
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We are dedicated to providing safe, effective and reliable products with rigorous quality control.
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We have industry-leading customer service and we are easy to do business with.