Excipients for Direct Compression Tablet Formulation

Highly reproducible excipients for direct compression tableting including lubricants, dry binders, sustained-release excipients, hot-melt granulation excipients and oil absorbing excipients.  

What Is Direct Compression?

Direct compression refers to the process of forming tablets by compressing a powder blend directly into a solid form. It relies on two key mechanisms:

Compaction: The formation of a solid tablet from powder.
Compression: The reduction in powder volume under pressure.

The direct compression method is preferred for its minimal processing steps, reduced production time, and lower energy consumption.

The Role of Excipients in Direct Compression

Excipient selection and performance is critical to the manufacture of robust tablets by direct compression. However, not all excipients behave the same under compression. For example, lubricants like magnesium stearate, while effective at reducing ejection force, can inhibit bonding between particles, leading to weaker tablets.

ABITEC manufactures a variety of excipients suitable for a multitude of tableting applications. They include lubricants, dry-binders, excipients for sustained release, and oil absorbents.

Challenges with Tablet Lubricants

Lubricants are essential to prevent damage to tablet presses and ensure smooth ejection. But they can also:

  • Reduce tablet hardness.
  • Prolong disintegration and dissolution times.
  • Interfere with active ingredient release.

How can ABITEC's innovative excipients for direct compressions help?

Why choose ABITEC for direct compression solutions?

  • ABITEC is is a global leader in the development and manufacture of highly reproducible, compendial lipid excipients for the pharmaceutical industry. 

  • We have spent over 50 years producing high-quality ingredients with world-class technical, scientific, regulatory and manufacturing expertise. 

  • Our pharmaceutical grade lipid excipients are manufactured under strict cGMP in an FDA-audited, state-of-the-art facility in Janesville, WI (USA).  

  • We are dedicated to providing safe, effective and reliable products with rigorous quality control.

  • We have industry-leading customer service and we are easy to do business with.