Emulsification

Emulsification of lipids and/or fatty acids allows them to be mixed with water-based substances, which has important implications for digestion. More specifically, in the area of drug delivery, emulsification plays a key role in the development of Self-Emulsifying Drug Delivery Systems (SEDDS) which enhance oral delivery and absorption of lipophilic drugs.  ABITEC offers a full portfolio of lipids that are useful as emulsifiers, co-emulsifiers, and surfactants.

Self-Emulsifying Drug Delivery System (SEDDS)

Lipid based drug delivery (LBDD) is an effective method of improving the solubility of BCS Class-II and Class-IV compounds and the permeability of certain BCS Class III and Class-IV compounds. ABITEC products are specifically designed for meeting the solubility challenges of the pharmaceutical industry. Our products can be used alone or in conjunction with one another to formulate a Self-Emulsifying Drug Delivery System (SEDDS) in order to improve the bioavailability of an active.

Formulating With SEDDS

Formulating With SEDDS

ABITEC's Dr. John K. Tillotson looks at the various methods available for manufacturing solid self-emulsifying drug delivery systems and explores the possibilities of optimizing these methods in the future.  

Related Products

ACCONON®

Acconon products represent a wide range of nonionic surfactants which are excellent primary or secondary emulsifiers in o/w systems. They are multifunctional products which are useful as dispersants, solubilizers, viscosity control agents, and refatting agents. The water and oil solubility (HLB) can be varied through alkoxylation of carefully selected raw materials that include oils, esters, alcohols, or fatty acids.

Product Name Chemical Name CAS Number
Acconon AKG-6 EP/NF* Oleoyl Macrogolglycerides 69071-70-1
Acconon C-44 EP/NF* Lauroyl Macrogoglycerides 67701-26-2
Acconon C-50 EP/NF* Stearoyl Macrogolglycerides or Stearoyl Polyoxylglycerides  121548-05-8
Acconon MC8-2 EP/NF Polyoxyethylene (8) Caprylic/Capric Glycerides 91744-32-0, 223129-75-7

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*Developmental

CAPMUL®

This line of highly-functional, highly reproducible medium and long chain monoglycerides can be used alone as a primary solubilizer, or in conjunction as an emulsifier with other ABITEC ingredients.

Applications include:

  • Effective in self-emulsifying drug delivery systems (SEDDS) when incorporatied as a low HLB water-in-oil (w/o) emulsifier or co-emulsifier
  • Emulsifier or co-emulsifier of choice in the preparation of stable, self-emulsifying lipid-based microemulsions
Product Name Chemical Name CAS Number
Capmul 808G EP/NF Glyceryl Monocaprylate 26402-26-6
Capmul GMO-50 EP/NF Glyceryl Monooleate 25496-72-4
Capmul MCM C8 EP/NF Glyceryl Monocaprylate 26402-26-6
Capmul MCM NF Glyceryl Caprylate/Caprate 91744-32-0,
26402-22-2,
26402-26-6
Capmul MCM EP/NF  Glyceryl Caprylate/Caprate  91744-32-0,
26402-22-2,
26402-26-6
Capmul PG-2L EP/NF Propylene Glycol Dilaurate 22788-19-8
Capmul PG-8 NF Propylene Glycol Monocaprylate 68332-79-6, or 31565-12-5
Capmul PG-8-70 NF Propylene Glycol Monocaprylate, NF Type 1 68332-79-6, or 31565-12-5
Capmul PG-12 EP/NF Propylene Glycol Monolaurate 27194-74-7

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